BIOENGINEERING AND SYNTHETIC BIOLOGY
Academic Year 2023/2024 - Teacher: GIUSEPPE NICOSIAExpected Learning Outcomes
The student will be introduced to the main approaches, methods and problems present in Bioengineering and Synthetic Biology.
Course Structure
The course includes lectures, exercises, seminars, tutorials, video lessons.
If the teaching is taught in mixed or remote mode, the necessary variations may be introduced with respect to what was previously declared, in order to respect the planned program and reported in the syllabus.
Required Prerequisites
Attendance of Lessons
Detailed Course Content
Introduction to bioengineering and synthetic biology
Complex networks for genetic and protein networks
Modelling synthetic biology by parts, devices and systems
Introduction to systems biology
Design of biological circuits
Genome and transcriptome analysis
Metabolic engineering
Computer-aided whole-cell design
Minimal cells
BioCAD for drug repurposing and design
Engineering of microorganisms for bioplastic and biofuel production
Applications of artificial intelligence and deep learning in synthetic and systems biology and bioengineering.
Textbook Information
Textbooks:
[1] W. Mark Saltzman, Biomedical Engineering: Bridging Medicine and Technology, Cambridge Texts in Biomedical Engineeirng, Cambridge University Press, 2nd Edition, June 2015.
[3] M. A. Marchisio, Introduction in Synthetic Biology – About Modeling, Computation, and Circuit Design, Springer, 2018.
[4] Uri Alon, An Introduction to Systems Biology – Design Principles of Biological Circuits, CRC Press – Taylor & Francis Group (Second Edition), 2020.
[5] Bernhard O. Palsson, Systems Biology Constraint-based Reconstruction and Analysis, Cambridge University Press, 2015.
[6] Alessandro Cellerino, Michele Sanguanini, Transcriptome Analysis, Edizioni della Scuola Normale Superiore, Pisa, 2018.
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Introduzione alla Bioingegneria | [1] |
| 2 | Reti Complesse per Circuiti Biologici (Reti Genetiche, Proteiche e Metaboliche) | [2] |
| 3 | Bioimaging | [1] |
| 4 | Introduzione alla biologia sintetica | [3] |
| 5 | Introduzione alla biologia dei sistemi | [4,5] |
| 6 | Progettazione di circuiti biologici | [4] |
| 7 | Ingegneria metabolica | [5] |
| 8 | Organoids-on-a-chip | [Dispense e Articoli] |
| 9 | Esempi di applicazioni di Intelligenza Artificiale e Deep Learning in ingegneria biomedica | [Dispense e Articoli] |
Learning Assessment
Learning Assessment Procedures
Project with technical report and presentation on a scientific article.
Learning assessment may also be carried out online, should the conditions require it.